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Times Like These

Imran Idris

It’s times like these you learn to live again
It’s times like these you give and give again
It’s times like these you learn to love again
It’s times like these time and time again…

Looking forward to another week of MRIs and neuropsychological testing. Never thought I’d say this, but I actually miss doing clinical work! Definitely considering starting a Cognitive Neurology Clinic once I’m back in Malaysia.

Have a good week everyone! Stay safe, and look out for each other.

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Dead Office Plant

Dead office plant

Location: Jericho, Oxford

Another (indirect) casualty of COVID-19.

See also:

Winter Coats, Apocalyptic Vibes Greet Workers Returning to Deserted Offices

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A Good Night’s Sleep

Someone asked me the other day if I had any good tips about how to get a good night’s sleep. I’ve written previously about how sleep is crucial for your cognitive abilities, but in truth, the benefits of sleep extend far beyond that. Sleep also helps to:

  • Reduce your cardiovascular risk
  • Prevent diabetes and obesity
  • Enhance the function of the immune system

…amongst many other benefits.

Like many things in life, it is important to get the balance right when it comes to sleep. Too much sleep is detrimental, obviously, but too little sleep can also be harmful. Our culture often glorifies people who can get by with very little sleep, when they are effectively just killing themselves slowly with their so-called ‘productivity’. Bottom line: apart from the quantity of sleep, the quality of sleep also matters.

So, how can we get a good night’s sleep? What brand of sleeping pill should we go out and buy?

The first thing to note is that sleeping pills are very poor treatments for insomnia (the medical term for when you have trouble falling and/or staying asleep). They don’t produce natural sleep; we know this by looking at what happens to your brainwaves when you sleep naturally vs when you are in a drug-induced sleep. Pills mostly work in the short-term only, with a risk of rebound insomnia when you stop treatment. Overall, I’d try my best to avoid sleeping pills if at all possible.

Tips for sleep

So, back to the original question: how do we get a good night’s sleep? For the vast majority of people, the best answer to that question is to learn how to develop good sleeping habits.

Thankfully, the National Institute on Aging has prepared some tips for developing good sleeping habits. I’m going to quote them (in bold text) here because they are excellent:

  • Follow a regular sleep schedule. In other words, go to sleep and get up at the same time each day.
  • Avoid napping in the late afternoon or evening. D’oh!
  • Develop a bedtime routine. Just like your computer needs some time to shut down, you also can benefit from having a ‘shutdown’ routine. It’s difficult to just fall asleep the moment your head hits the pillow. Much better to relax before bedtime in order to prepare you for sleep.
  • Try not to watch television or use your computer, smartphone, or tablet in the bedroom. Stop refreshing your Facebook feeds and read a good book instead.
  • Keep your bedroom at a comfortable temperature. This is an opportunity to practise your diplomacy skills i.e. when trying to reach an agreement with the spouse as to what a ‘comfortable temperature’ is.
  • Use low lighting in the evenings.
  • Exercise at regular times each day. Ideally, not within 2-3 hours of bedtime so that you body has time for its shutdown routine.
  • Avoid eating large meals close to bedtime.
  • Stay away from caffeine late in the day. Caffeine can take up to 8 hours to wear off fully. Nicotine is also a stimulant, so yeah, stop smoking before bedtime. Also, stop smoking during the day. In fact, just stop smoking OK?
  • Remember—alcohol won’t help you sleep. No nightcaps please.

I hope the above information will help you get a good night’s sleep.

Finally, if all else fails, there’s always the audiobook of Samuel L. Jackson reading ‘Go the F**k to Sleep‘. You’re welcome!

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Leuchtturm 1917

The key to happiness is learning to appreciate the little things in life, like this Leuchtturm 1917 notebook that I’ve just bought for a super secret project of mine.

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Train Your Brain

Wouldn’t it be nice to be able to pop a pill and magically become smarter? Of course it would. In the movie Limitless, struggling writer Edward Morra tries a new nootropic drug called NZT-48 and suddenly turns into a genius. Absolutely brilliant, job done, see you later!

Naturally, things are not so straightforward in real life. A recent study by Cohen et al published in Neurology Clinical Practice (DOI: 10.1212/CPJ.0000000000000960) found that many over-the-counter (OTC) cognitive enhancement supplements also contain unapproved drugs. A supplement to supplement your supplement, if you like. The authors conclude by saying that ‘the health effects of consuming untested combinations of unapproved drugs at unpredictable dosages without clinician oversight in supplements is unknown’ (emphasis mine).

Unfortunately, many people still believe in the power of OTC supplements to boost their cognitive abilities. Why is this so? I think it has to do with our desire to shortcut the process to becoming more intelligent. I mean, who’s got the time to read all these books eh? TL;DR…lukis boleh? Etc.

Let’s make it clear then: if you want to be a smart person, the smartest thing you can do right now is to stop buying all these nonsense supplements. None of them have been shown to work, and you might as well donate the money to a more deserving cause.

How To Train Your Brain

So, is there nothing that we can do to train our brains to become smarter?

Of course not. Here are some easy-to-implement suggestions:

1. Get Enough Sleep

In his book ‘Why We Sleep’, neuroscientist Matthew Walker came up with this fictitious advertisement to highlight the benefits of a full night of sleep.

Scientists have discovered a revolutionary new treatment that makes you live longer. It enhances your memory and makes you more creative. It makes you look more attractive. It keeps you slim and lowers food cravings.It protects you from cancer and dementia. It wards off colds and the flu. It lowers your risk of heart attacks and stroke, not to mention diabetes. You’ll even feel happier, less depressed, and less anxious. Are you interested?

Walker goes on to make the point that if this were a drug, people would be paying exorbitant amounts just to get a small dose into their systems. Unlike the claims made by OTC supplements however, all the above statements about sleep can be backed up by solid evidence.

So, why don’t people promote sleep as a treatment for all these conditions?

My guess is because it’s hard to make money from sleep. You can’t sell it, you can’t buy it for others, and worse still, people who are sleeping tend not to be such excellent consumers. Hard to imagine buying things on Shopee or Lazada while you’re fast asleep!

Bear in mind that we’re talking about good quality sleep here. A full night of sleep begins with your pre-sleep ritual. Do you spend an hour browsing through your Facebook/Instagram feeds, or do you switch off all screens and read a book instead? While you’re sleeping, is your phone still buzzing away with all sorts of useless notifications? These things matter when it comes to determining the quality of your sleep.

2. Healthy Body, Healthy Mind

Apart from getting a full night of sleep, you also need to think about your general physical health. Everyone knows what I mean by that: eat a balanced diet, get enough exercise, stop smoking etc. These measures are not controversial, but if you still want some evidence, check out this recent paper by my colleagues Michele Veldsman and Xin-You Tai in Nature Communications (DOI: 10.1038/s41467-020-18201-5) entitled ‘Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing’. One of their key findings is that:

…cerebrovascular risk is associated with reduced cerebral grey matter and white matter integrity within a fronto-parietal brain network underlying executive function.

3. Challenge Your Brain

These days, it is easy to just go through life like a mindless zombie. Many forms of entertainment are effectively infinity pools, designed to suck you in and keep you there for as long as possible. As soon as one YouTube video ends, the next one plays automatically. You can never get to the bottom of your Facebook or Twitter feed thanks to infinity scrolling.

It’s time to break the cycle!

We need to be more mindful about what we feed our minds. Instead of refreshing Instagram for the millionth time, why not try something more cognitively demanding?

Read a good book, solve some Sudoku puzzles, join a really good discussion about current affairs, switch off Google Maps and try to navigate manually, there are endless possibilities for giving your brain a really good challenge.

For Muslims, here’s my personal suggestion: try to memorise the Quran. Whether you get there in the end (i.e. whether you actually manage to memorise all of it) doesn’t really matter. What matters is your effort and ‘istiqamah‘ in doing so. Progress, not perfection. That way, you get to do something cognitively demanding, and spiritually rewarding at the same time.

4. Connect With Others

Last but not least, try to maintain healthy, meaningful connections with others. One of the greatest ironies in today’s world is that we are more connected than ever (thanks to social media) but increasingly becoming more distant from each other.

Most of our relationships are very superficial, reduced to mere ‘Likes’ on Facebook or Instagram. We often know what random celebrities had for breakfast, but don’t even realise that a friend or relative is suffering a serious illness.

How does maintaining healthy relationships make us smarter?

Part of it is the psychological benefit of having a good support network. Part of it is the physical well-being you get from doing various activities together. And a large part of it, I believe, is due to the complex, intricate, delicate nature of human relationships, one that can never be replaced by social media stardom.

It reminds me of this scene from Inception (one of the best movies of all time, by the way) in which Dominick “Dom” Cobb finally makes peace with his guilt over the death of his wife Mal:

Mal: I’m the only thing you do believe in anymore.

Dom: I wish. I wish more than anything, but…I can’t imagine you with all your complexity, all your perfection, all your imperfection. Look at you. You’re just a shade. You’re just a shade of my real wife. And you were the best that I could do, but…I’m sorry, you’re just not good enough.

Inception

I’m not crying, you’re crying. Damn ninjas cutting onions!

So, in summary:

  1. Get enough sleep.
  2. Eat a balanced diet. Get enough exercise. Stop smoking etc.
  3. Do cognitively demanding activities.
  4. Maintain healthy relationships.
  5. Stop buying useless OTC drugs! =)
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Punts At Rest

Punts at rest.

Location: Magdalen Bridge, Oxford

Fancy going punting in the rain? Guess not.

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Questions

From Kottke.org:

The winning entries from the Insight Investment Astronomy Photographer of the Year 2020 competition are here and they are spectacular.

Spectacular doesn’t even begin to describe some of these images!

Here’s my absolute favourite:

This image, entitled ‘Questions’, was taken by New Zealand based photographer Paul Wilson. (Check out his other photos by the way, they are simply mind-blowing!)

Looking at the galaxies above us, one cannot help but wonder how all of this came into existence. All this beauty in the universe, all this majesty, surely it must exist for a reason. I know this is a deeply personal question, one that depends, to a large extent, on your faith and how you view the world around you. For me though, the answer is clear.

The Holy Quran states:

There truly are signs in the creation of the heavens and earth, and in the alternation of night and day, for those with understanding, who remember God standing, sitting, and lying down, who reflect on the creation of the heavens and earth: ‘Our Lord! You have not created all this without purpose—You are far above that!—so protect us from the torment of the Fire.’

Surah Ali-Imran [3:190-191]
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Beaumont Palace

Beaumont Palace

Near to this site stood the King’s houses later known as Beaumont Palace

King Richard I was born here in 1157 and King John in 1167

If you walk down Beaumont Street from the Ashmolean Museum towards Worcester College, you may come across a small pillar near the junction with Walton Street. It’s partly hidden by bushes, but you can just about see it in the image from Google Street View below (on the right side of the picture, next to the man walking on the pavement):

Beaumont Street

Originally built in the early 12th century by Henry I outside the north gate of Oxford, Beaumont Palace was partly dismantled following the Reformation. What remains of the palace was eventually torn down in the laying out of Beaumont Street in 1829.

All that’s left now is a pillar, and memories of times long past.

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Creepy Weird Nerds

Finally, someone who appreciates our talent! I can’t wait to show my kids what the famous comedian Dr Jason ‘Jho Low’ Leong says about neurologists. Haha.

In all seriousness, not a day goes by without me feeling #blessed to be in this position.

In case you’ve missed all the announcements, Hashtag Blessed is now available on Netflix.

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Can Maths Tell Us How to Win at Fantasy Football?

It’s that time of the year again! Payback for all the instances you were picked last when choosing teams. Redemption for all the missed kicks, headers, and tackles when you were a kid. A chance for nerds everywhere to finally prove their worth on the football field. Fantasy Football, that is…

If you’re interested in learning about mathematically-optimal strategies for Fantasy Football (and who isn’t?), here’s a lecture on the topic given by Josh Bull from the Mathematical Institute at Oxford.

You may rightly ask, what do scientists/geeks/nerds know about Fantasy Football anyway? Actually, more than you might think. Josh, for example, won the 2019-2020 Premier League Fantasy Football competition, partly using mathematical modelling strategies carried over from his work on cancer cells.

As Jack Black says (or sings) in the School of Rock:

Math is a wonderful thing
Math is a really cool thing
So get off your act let’s do some math
Math, math, math, math, math